Is it possible to run two cron jobs - one for Google Drive (daily) and one to AmazonS3 (monthly). Can this be achieved by using different profiles in akeebabackup?

Correct. This is exactly what you have to do. Create one profile for Google Drive and one for Amazon S3. Create one CRON job per profile.

  1. Backup with the default profile (ID = 1) and default description:

    usr/local/bin/php /home/johndoe/httpdocs/cli/akeeba-backup.php
  2. Backup with profile number 2 and default description:

    usr/local/bin/php /home/johndoe/httpdocs/cli/akeeba-backup.php --profile=2

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Lancaster